Cobalt Chloride Treatment and Iron Metabolism in Immature Mice

Although cobalt is an essential trace element, it is toxic in high concentrations. Long-term exposure to cobalt chloride (CoCl2) significantly increases Co(II) ions in blood serum, spleen and liver of treated immature mice compared to controls and induces changes in the iron (Fe) content. Spleen and liver show different sensitivity to Co(II) administration but increase iron storage. The three experimental groups of immature mice – day 18-, 25and 30, used in the experimental design, show different sensitivity to the metal. This suggests that the stage of development is also an important marker that should be considered.